Mammographic density and epithelial histopathologic markers
نویسندگان
چکیده
منابع مشابه
Mammographic density and histopathologic characteristics of screen-detected tumors in the Norwegian Breast Cancer Screening Program
BACKGROUND High mammographic density might mask breast tumors, resulting in delayed diagnosis or missed cancers. PURPOSE To investigate the association between mammographic density and histopathologic tumor characteristics (histologic type, size, grade, and lymph node status) among women screened in the Norwegian Breast Cancer Screening Program. MATERIAL AND METHODS Information about 1760 s...
متن کاملQuantifying Effect-Specific Mammographic Density
A methodology is introduced for the automated assessment of structural changes of breast tissue in mammograms. It employs a generic machine learning framework and provides objective breast density measures quantifying the specific biological effects of interest. In several illustrative experiments on data from a clinical trial, it is shown that the proposed method can quantify effects caused by...
متن کاملThe Pathobiology of Mammographic Density
High mammographic density confers a significantly increased risk of breast cancer. As it is relatively common in the normal population the risk of cancer attributable to increased mammographic density could potentially account for an important percentage of total BCa cases. The underlying cause for high mammographic density and its association with increased BCa risk and progression is unknown....
متن کاملMicroenvironment and Immunology Stress Signaling from Human Mammary Epithelial Cells Contributes to Phenotypes of Mammographic Density
Telomere malfunction and other types of DNA damage induce an activin A–dependent stress response in mortal nontumorigenic human mammary epithelial cells that subsequently induces desmoplastic-like phenotypes in neighboring fibroblasts. Some characteristics of this fibroblast/stromal response, such as reduced adipocytes and increased extracellular matrix content, are observed not only in tumor t...
متن کاملRotating night shift work and mammographic density.
BACKGROUND An increased risk of breast cancer has been observed in night shift workers. Exposure to artificial light at night and disruption of the endogenous circadian rhythm with suppression of the melatonin synthesis have been suggested mechanisms. We investigated the hypothesis that rotating night shift work is associated with mammographic density. METHODS We conducted a cross-sectional s...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2009
ISSN: 1471-2407
DOI: 10.1186/1471-2407-9-182